In biology, medicine, and technology, chemical synthesis of small molecules performs very important functions. However, the small compound synthesis is no easy thing, limitations to the synthesis impede the development of small molecules. Chemists are thinking about their solutions to the current situation. And a “block by block” way is come up with by the researchers. It is found that small molecules possess a similar capacity to generalize block-based building construction and according to this, a general building block can be set for a machine to put the molecules together in an assembly-line fashion.