Selection of Synthetic Routes in Organic Chemistry

The design and selection of synthetic routes are the core of a chemical synthesis lab. It reflects the basic skills and richness of knowledge and flexible mind of an organic synthesizer. In general, the choice and design of synthesis routes represent a person’s synthetic level and quality. A reasonable synthetic route can quickly obtain the target compound, while a clumsy synthetic route can finally obtain the target compound, but the price paid is a waste of time and an increase in synthesis cost. Therefore, the selection and design of synthetic routes are very important.Synthetic Routes

The criteria for selecting the synthetic routes in organic chemistry

The selection and design of the synthetic routes should be based on the purpose of obtaining the target compound.

For industry use

If the target compound is obtained for the purpose of industrial production, the selected synthetic route should be based on the lowest synthesis cost.

In general, a brief synthesis route should have a higher total yield of the reaction, so the synthesis cost is the lowest, while the long synthetic route has a lower total yield and higher synthesis cost. However, in some cases, the longer synthetic route may cost less than the shorter one since it has a higher reaction rate during each step, and cheaper reagents used. The shorter synthetic route has a lower yield per reaction, and the reagents used are expensive, and the synthesis cost is higher. Therefore, if industrial production is the goal, the selection and design of synthetic routes should be based on the principle of the lowest synthetic cost calculated, and actual results.

For academic research

If the target compound is obtained for the purpose of academic research, like publishing a paper, the selection and design of the synthetic route have different principles. The route of the design should be as creative as possible, with new ideas, the reagents used should be novel, and the reaction conditions should be innovative. At this time, the main issue considered is not the issue of synthesis cost but the issue of creativity in synthesis.

Some other suggestions regarding synthetic routes in organic chemistry

If you are synthesizing a series of compounds, when designing a synthetic route, the common steps should be as long as possible. Each compound is only different in the final synthetic step. Then such a synthetic route is more reasonable and efficient. A large number of target compounds were obtained in a short time. The synthetic route of each target compound generally has multiple reactions. In order to avoid the problem of impurity amplification, the best solution is to divide the synthetic route into two and convert them into two intermediates. Finally, the two intermediates are reacted in one step and assembled to get the target compound. Try to avoid continuous reaction to get the product only in the last step.

The selection of synthetic routes in organic chemistry is of great importance for companies offering custom synthesis services. Only by knowing the suitable solution for synthesizing the desired compound can both parties benefit from each other.